The Lloyd-Smith Laboratory at UCLA

I am interested in the processes underlying the circulation of infectious agents among hosts. As mechanisms occurring at different scales (through time, space and biological systems) interact together to drive epidemiological dynamics, my main research interest is in the development of methods allowing efficient data integration to identify and quantify these processes.

During my PhD (supervised by Thierry Boulinier, CEFE - CNRS/Montpellier University, France), I explored in which conditions and how serological data can be used to efficiently infer the underlying processes of infectious agent circulation and their effects on hosts in wild populations. For this, I combined observational and experimental data collected in various seabird-parasite systems (as part of the ECOPATH, PARASITO-ARCTIQUE and ECOPOP projects) with theoretical approaches. I notably illustrated the benefit of using longitudinal epidemiological data collected as part of population ecology researches to study the circulation of infectious agents in wild populations and proposed a method inspired from the integrated population modelling framework to quantify the force of infection by combining cross-sectional and longitudinal serological data.

My current research as postdoc here in the Lloyd-Smith Lab aims at designing quantitative methods to integrate epidemiological data collected in the lab and in the field, at scales from molecules to communities, with the goal of developing biological insight and practical predictors of the epidemiological dynamics of pathogenic infectious agents in multi-host systems. For this, I combine mathematical modelling and empirical data analyses. My main study systems are (1) emerging zoonotic viruses, in particular paramyxoviruses and coronaviruses, in human and other animal populations (as part of the BatOneHealth project) and (2) Leptospira bacteria in California sea lions and island foxes.

Online:

- ORCID profile

- ResearchGate profile

- Publons profile

- Twitter @AmandineGamble

Last updated in September 2021. For a more recent update, check out my Google Scholar page.

* equal contribution

Peer-reviewed publications

Ruiz-Aravena M.*, McKee C.*, Gamble A., Lunn T., Morris A., Snedden C.E., Yinda K.C., Port J., Buchholz D.W., Yeo Y.Y., Faust C., Jax E., Dee L., Jones D., Kessler M., Falvo C., Crowley D., Bharti N., Brook C.E., Aguilar H.C., Peel A.J., Restif O., Schountz T., Parrish C.R., Gurley E.S., Lloyd-Smith J.O., Hudson P., Munster V.J. and Plowright R.K. (2021). Ecology, evolution, and spillover of coronaviruses from bats. Nature Reviews Microbiology, in press.

Ponchon A., Gamble A., Ahtiainen I.V., Tornos J., Delord K., Barbraud C., Travis J.M.J., Weimerskirch H. and Boulinier T. (2021). Similar at-sea behaviour but different habitat use between failed and successful breeding albatrosses. Marine Ecology Progress Series, in press.

Gamble A., Yeo Y.Y.*, Butler A.A.*, Tang H., Snedden C.E., Mason C.T., Buchholz D.W., Bingham J., Aguilar H.C. and Lloyd-Smith J.O. (2021). Drivers and distribution of henipavirus-induced syncytia: what do we know? Viruses 13, 1755. DOI: 10.3390/v13091755

Gamble A.*, Fischer R.J.*, Morris D.H., Yinda K.C., Munster V.J. and Lloyd-Smith J.O. (2021). Heat-treated virus inactivation rate depends strongly on treatment procedure: illustration with SARS-CoV-2. Applied and Environmental Microbiology 87, e00314-21. DOI: 10.1128/aem.00314-21

Yeo Y.Y., Buchholz D.W., Gamble A., Jager M. and Aguilar H.C (2021). Headless henipaviral receptor binding glycoproteins reveal inefficient Cedar virus fusion modulated by the head/stalk interface. Journal of Virology 95, e00666-21 . DOI: 10.1128/JVI.00666-21

Snedden C.E.*, Makanani S.K.*, Schwartz S.T., Gamble A., Blakey R.V., Borremans B., Helman S.K., Espericueta L., Valencia A., Endo A., Alfaro M.E. and Lloyd-Smith J.O. (2021). SARS-CoV-2: cross-scale insights from ecology and evolution. Trends in Microbiology 29, 593-605 . DOI: 10.1016/j.tim.2021.03.013

Morris D.H.*, Yinda K.C.*, Gamble A.*, Rossine F.W., Huang Q., Bushmaker T., Fischer R.J., Matson M.J., van Doremalen N., Vikesland P.J., Marr L.C., Munster V.J. and Lloyd-Smith J.O. (2021). Mechanistic theory predicts the effects of temperature and humidity on inactivation of SARS-CoV-2 and other enveloped viruses. eLife 10, e65902. DOI: 10.7554/eLife.65902

Barbosa A., Varsani A., Morandini V., Grimaldi W., Vanstreels R.E.T., Diaz J.I., Boulinier T., Dewar M., González-Acuña D., Gray R., McMahon C.R., Miller G., Power M., Gamble A.* and Wille M.* (2020). Risk assessment of SARS-CoV-2 in Antarctic wildlife. Science of the Total Environment 755, 143352. DOI: 10.1016/j.scitotenv.2020.143352

Borremans B., Gamble A., Prager K.C., Helman S.K., McClain A.M., Cox C., Savage V. and Lloyd-Smith J.O. (2020). Quantifying antibody kinetics and RNA shedding during early-phase SARS-CoV-2 infection. eLife 9, e60122. DOI: 10.7554/eLife.60122

Fischer R.J.*, Morris D.H.*, van Doremalen N., Sarchette S., Matson J., Bushmaker T., Yinda C.K., Seifert S., Gamble A., Williamson B., Judson S., de Wit E., Lloyd-Smith J.O. and Munster V.J. (2020). Effectiveness of N95 respirator decontamination and reuse against SARS-CoV-2 virus. Emerging Infectious Diseases 26, 2253. DOI: 10.3201/eid2609.201524

Jaeger A.*, Gamble A.*, Lagadec E.*, Lebarbenchon C., Bourret V., Tornos J., Barbraud C., Delord K., Weimerskirch H., Thiebot J.-B., Boulinier T. and Tortosa P. (2019). Impact of Annual Bacterial Epizootics on Albatross Population on a Remote Island. EcoHealth 17, 194-202. DOI: 10.1007/s10393-020-01487-8

van Doremalen N.*, Bushmaker T.*, Morris D.H.*, Holbrook M.G., Gamble A., Williamson B.N., Tamin A., Harcourt J.L., Thornburg N.J., Gerber S.I., Lloyd-Smith J.O., de Wit E. and Munster V.J. (2020). Aerosol and surface stability of SARS-CoV-2 as compared with SARS-CoV-1. New England Journal of Medicine 382, 1564-1567. DOI: 10.1056/NEJMc2004973

Gamble A., Bazire R., Delord K., Barbraud C., Jaeger A., Gantelet H., Thibault E., Lebarbenchon C., Lagadec E., Tortosa P., Weimerskirch H., Thiebot J.-B., Garnier R., Tornos J. and Boulinier T. (2019). Predator and scavenger movements among and within endangered seabird colonies: opportunities for pathogen spread.. Journal of Applied Ecology 57, 367-378. DOI: 10.1111/1365-2664.13531

Gamble A., Garnier R., Chambert T., Gimenez O. and Boulinier T. (2019). Next generation serology: integrating cross-sectional and capture-recapture approaches to infer disease dynamics. Ecology 101, e02923. DOI: 10.1002/ecy.2923

Sanz-Aguilar A., Payo-Payo A., Rotger A., Moutailler S., Igual J.M., Miranda M.A., Torres M., Picorelli V., Gamble A. and Boulinier T. (2019). Infestation of small seabirds by Ornithodorus maritimus ticks: effects on chick body condition, reproduction and associated infectious agents. Ticks and Tick-borne Diseases 11, 101281. DOI: 10.1016/j.ttbdis.2019.101281

Gamble A., Garnier R., Jaeger A., Thibault E., Gantelet H., Tortosa P., Bourret V., Thiebot J.-B., Delord K., Weimerskirch H., Tornos J., Barbraud C. and Boulinier T. (2019). Exposure of albatrosses to the avian cholera agent leads to a short-lived immune response: implications for disease surveillance and management. Oecologia 189, 939-949. DOI: 10.1007/s00442-019-04369-1

Gamble A., Ramos R., Parra-Torres Y., Mercier A., Galal L., Pearce-Duvet J.M.C., Villena I., Montalvo T., Gonzalez-Solis J., Hammouda A., Oro D., Selmi S. and Boulinier T. (2019). Exposure of yellow-legged gulls to Toxoplasma gondii along the Western Mediterranean coasts: tales from a sentinel. International Journal for Parasitology: Parasites and Wildlife 8, 221-228. DOI: 10.1016/j.ijppaw.2019.01.002

Bourret V., Gamble A., Tornos J., Jaeger A., Delord K., Barbraud C., Tortosa P., Kada S., Thiebot J.-B., Thibault E., Gantelet H., Weimerskirch H., Garnier R. and Boulinier T. (2018). Vaccination protects endangered albatross chicks against avian cholera. Conservation Letters 11, e12443. DOI: 10.1111/conl.12443

Boulinier T., Kada S., Ponchon A., Dupraz M., Dietrich M., Gamble A., Bourret V., Duriez O., Bazire R., Tornos J., Tveraa T., Chambert T., Garnier R. and McCoy K.D. (2016). Migration, prospecting, dispersal? What host movement matters for infectious agent circulation? Integrative and Comparative Biology 56, 330-342. DOI: 10.1093/icb/icw015

Illustrative notes

Gamble A., Weimerskirch H. and Boulinier T. (2020). Seabirds blinded by ticks. Frontiers in Ecology and the Environment, in press. DOI: 10.1002/fee.2237

Gamble A., Garnier R., Chambert T. Gimenez O. and Boulinier T. (2020). Next-generation serology: integrating cross-sectional and capture-recapture approaches to infer disease dynamics. The Bulletin of the Ecological Society of America 101, e01670. DOI: 10.1002/bes2.1670

Reports

Boulinier T., Betoulle S., Caza F., St Pierre Y., Tornos J., Gamble A. and Tasiemski A. (2020). Panorama des recherches et des derniers résultats sur les pathogènes en milieu polaire. IPEV 2018: Rapport d'activité, 54-65

Boulinier T., Gamble A., Tornos J. and Garnier R. (2017). Circulation d’agents infectieux dans les populations de vertébrés coloniaux des terres australes : surveillance, compréhension et implications pour la gestion. IPEV 2016 : Rapport d'activité, 52-61

Blog posts

Tracking predator movements to understand pathogen spread. Nature Research Ecology & Evolution Community, 1 November 2020

Predator and scavenger movements as opportunities for pathogen spread among endangered seabirds. The Applied Ecologist's Blog, 21 January 2020. French translation also available

Tracking predator and scavenger movements to understand pathogen spread among endangered seabirds. Zone Atelier Antarctique LTSER, 9 January 2020

Online talks

Seminar. Linking exposure dose to infectious disease development using mechanistic models. UCLA QCBio Seminar, 26 February 2021, Los Angeles, CA, USA

Public talk. Comprendre et contrôler les pandémies zoonotiques en intégrant écologie, virologie et mathématiques. Café des Science, Consulate General of France in Los Angeles, 3 December 2020, Los Angeles, CA, USA

Amandine Gamble

Amandine Gamble

Research Interests

Publications